Rage Against The Machine were forced to stanch their headline set on the Main Stage at Leeds Festival tonight (August 23) to prevent a crowd crush.
The band stopped abruptly nigh the end of fourth track 'Bombtrack', and isaac M. Singer Zack de la Rocha asked the crowd to all pack a few steps back.
It is believed a jam was seen to be developing in the audience by security measures, who informed the band of the situation in order to avoid whatever injury.
Rage Against The Machine paused their put for about three minutes while the crowd stirred back, then launched fiercely back into 'Bombtrack' where they had left off.
The band took to the stage in their usual clothes tonight, rather than the Guantanamo-style boilersuits they came on with at Reading Festival last night (August 22).
The setlist was also slightly different from last night, omitting fan favourite 'Wake Up' and adding in tracks such as 'Renegades Of Funk' and 'Down Rodeo'.
Frontman de la Rocha said little passim the coif, which byword a massive crowd - who regularly gasped and cheered at Tom Morello's guitarwork - turn up to see the ring, .
The band linked blazon and raised fists as they left hand the stage after the band's regular closer and crowd favourite 'Killing In The Name'.
Rage Against The Machine played:
'Testify'
'Bulls On Parade'
'People Of The Sun'
'Bombtrack'
'Know Your Enemy'
'Bullet In The Head'
'Renegades Of Funk'
'Guerilla Radio'
'Down Rodeo'
'Calm Like A Bomb'
'Sleep Now In The Fire'
'War Within A Breath'
'Freedom'
'Killing In The Name'
NME.COM is bringing you live insurance coverage straight from both sites of the Reading And Leeds Festivals 2008. For the latest news, blogs, pictures and video interviews head to the Reading And Leeds Festivals index finger now.
Plus have sure you get next week's progeny of NME - on newsstands countrywide from Wednesday August 27 - for the ultimate Reading And Leeds Festivals review.
For more Reading And Leeds Festivals coverage including live footage and more, visit fellow official media partner bbc.co.uk/readingandleeds.
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Tuesday, 26 August 2008
Saturday, 16 August 2008
Some Types Of Leukemia Are Addicted To Notch Proteins
�The leukemic cells in a tumid proportion of individuals with a variant of leucaemia known as T-ALL receive mutations in the NOTCH1 gene. These mutations lede to the generation of Notch1 proteins that have increased body process, however, it is non known whether they have sufficient increased activity to actually initiate the disease.
New data, generated by a team of researchers, at the University of Pennsylvania School of Medicine, Philadelphia, and Brigham and Women's Hospital, Boston, have now indicated that only uncommon T-ALL-associated NOTCH1 mutations have the ability to induce cells to become leukemic in mice (these uncommon mutations generated Notch1 proteins with far greater increased activity than the Notch1 proteins generated by the more common mutations).
However, although the more than common mutations were non themselves able to cause cells to become leukemic in mice, they were able to accelerate the onset of leukemia induced by other genetic mutations.
The authors therefore indicate that all T-ALL leukemic cells with mutations in the NOTCH1 gene ar "addicted" to Notch and that this study provides support for the rating of Notch signaling pathway inhibitors as a treatment for cancer of the blood.
"Leukemia-associated NOTCH1 alleles ar weak tumour initiators just accelerate K-ras-initiated leukemia"
Mark Y. Chiang, Lanwei Xu, Olga Shestova, Gavin Histen, Sarah L'Heureux, Candice Romany, M. Eden Childs, Phyllis A. Gimotty, Jon C. Aster and Warren S. Pear
J. Clin. Invest. doi:10.1172/JCI35090
Click here to view clause online
The Journal of Clinical Investigation (JCI) is the publication of the American Society for Clinical Investigation, an honor society of physician-scientists.
www.jci.org
More info
New data, generated by a team of researchers, at the University of Pennsylvania School of Medicine, Philadelphia, and Brigham and Women's Hospital, Boston, have now indicated that only uncommon T-ALL-associated NOTCH1 mutations have the ability to induce cells to become leukemic in mice (these uncommon mutations generated Notch1 proteins with far greater increased activity than the Notch1 proteins generated by the more common mutations).
However, although the more than common mutations were non themselves able to cause cells to become leukemic in mice, they were able to accelerate the onset of leukemia induced by other genetic mutations.
The authors therefore indicate that all T-ALL leukemic cells with mutations in the NOTCH1 gene ar "addicted" to Notch and that this study provides support for the rating of Notch signaling pathway inhibitors as a treatment for cancer of the blood.
"Leukemia-associated NOTCH1 alleles ar weak tumour initiators just accelerate K-ras-initiated leukemia"
Mark Y. Chiang, Lanwei Xu, Olga Shestova, Gavin Histen, Sarah L'Heureux, Candice Romany, M. Eden Childs, Phyllis A. Gimotty, Jon C. Aster and Warren S. Pear
J. Clin. Invest. doi:10.1172/JCI35090
Click here to view clause online
The Journal of Clinical Investigation (JCI) is the publication of the American Society for Clinical Investigation, an honor society of physician-scientists.
www.jci.org
More info
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Thursday, 7 August 2008
Delta Goodrem: Elevation
When Delta Goodrem was cast in Australia's long-running serial "Neighbours" in 2002, the adolescent didn't care for the "bad girl" character written for her -- and had the audacity to renege on the potentially career-making persona.
Goodrem had already signed a development deal with Sony Records and felt the part didn't suit the hopeful tone of her music. "It's hard now to believe I had the courage to do that," the 23-year-old says. But as it turns out, show producers wanted to fly with Delta and rewrote the role of shy coffee-shop staffer/budding singer "Nina Tucker" to her liking�and she signed on.
Goodrem has certainly made good on not being bad�but her story has since played out with more real-life melodrama than any soap. When her latest album, "Delta," arrives July 15, it will represent the culmination of five topsy-turvy years.
Her first single "Born to Try" (Columbia)�introduced on "Neighbours" in 2003�rallied to No. 1 at home in Oz, while her debut album "Innocent Eyes" spent 29 weeks as a chart-topper, selling 14-times platinum and winning seven Australian Recording Industry Assn. Awards. The record also made her a star in the United Kingdom, Ireland, Greece, Sweden and Japan.
And then her career came to a precipitous halt when late that year, at 18, she was diagnosed with Hodgkin's lymphoma, a cancer that attacks the immune system. A U.S. launch on Columbia was compromised; single "Lost Without You" reached No. 18 at AC, but too weak to promote it, Goodrem's planned album was scrapped.
After chemotherapy and radiation, her 2004 sophomore CD "Mistaken Identity" was released in established territories and, not surprisingly, displayed a starker lyrical side. Goodrem says, "I was young, but never na�ve, and found strength as a woman. I know it was intense, even tiring." Fans stood alongside (even as she retired from "Neighbours"), with another No. 1. Then, "Delta" in 2007 became her third consecutive chart-topping disc. "The title reflects that I'm my own person now, I've learned a lot," she says. "You can only control so much in life."
Now, she returns to the States�all told with a string of eight No. 1s among 13 top 40 Australian singles to date. Signed to Mercury's resurrected imprint Decca in the U.S., Goodrem has a mighty proponent in label president David Massey�a former global A&R exec for Sony who was integral in grooming her in 2002.
It's a slightly reconfigured "Delta" arriving Stateside. The first single, the uptempo, piano-fervent "In This Life"�produced by Grammy Award winner John Shanks and co-written by Goodrem and fianc� Bryan McFadden (formerly of hitmaking Irish boy band Westlife)�is bulleted at No. 35 at adult top 40. She's partnered with ION Television for its fall launch, including on-air imaging and exposure of "In This Life" and "Believe Again" (a No. 2 single in Oz). She'll appear at the American Cancer Society's fall charity Dreamball and the Jorge Posada Foundation's seventh annual Heroes of Hope Gala, hosted by Kelly Ripa, both in New York.
In addition, Goodrem recorded a duet, "Right Here With You," with fellow Aussie and cancer survivor Olivia Newton-John for the July album release "Olivia Newton-John & Friends: A Celebration in Song," with proceeds to benefit her Cancer and Wellness Centre.
"It's even more rewarding that I get to come back and start properly," Goodrem says of her U.S. relaunch. "I'm hungry for this and committed to being a new artist. I feel like I was always meant to do this, like there's a chip in my body that says, 'OK, what's next?'"
Additional reporting by Christie Eliezer in Melbourne and Andre Paine in London.
More info
Goodrem had already signed a development deal with Sony Records and felt the part didn't suit the hopeful tone of her music. "It's hard now to believe I had the courage to do that," the 23-year-old says. But as it turns out, show producers wanted to fly with Delta and rewrote the role of shy coffee-shop staffer/budding singer "Nina Tucker" to her liking�and she signed on.
Goodrem has certainly made good on not being bad�but her story has since played out with more real-life melodrama than any soap. When her latest album, "Delta," arrives July 15, it will represent the culmination of five topsy-turvy years.
Her first single "Born to Try" (Columbia)�introduced on "Neighbours" in 2003�rallied to No. 1 at home in Oz, while her debut album "Innocent Eyes" spent 29 weeks as a chart-topper, selling 14-times platinum and winning seven Australian Recording Industry Assn. Awards. The record also made her a star in the United Kingdom, Ireland, Greece, Sweden and Japan.
And then her career came to a precipitous halt when late that year, at 18, she was diagnosed with Hodgkin's lymphoma, a cancer that attacks the immune system. A U.S. launch on Columbia was compromised; single "Lost Without You" reached No. 18 at AC, but too weak to promote it, Goodrem's planned album was scrapped.
After chemotherapy and radiation, her 2004 sophomore CD "Mistaken Identity" was released in established territories and, not surprisingly, displayed a starker lyrical side. Goodrem says, "I was young, but never na�ve, and found strength as a woman. I know it was intense, even tiring." Fans stood alongside (even as she retired from "Neighbours"), with another No. 1. Then, "Delta" in 2007 became her third consecutive chart-topping disc. "The title reflects that I'm my own person now, I've learned a lot," she says. "You can only control so much in life."
Now, she returns to the States�all told with a string of eight No. 1s among 13 top 40 Australian singles to date. Signed to Mercury's resurrected imprint Decca in the U.S., Goodrem has a mighty proponent in label president David Massey�a former global A&R exec for Sony who was integral in grooming her in 2002.
It's a slightly reconfigured "Delta" arriving Stateside. The first single, the uptempo, piano-fervent "In This Life"�produced by Grammy Award winner John Shanks and co-written by Goodrem and fianc� Bryan McFadden (formerly of hitmaking Irish boy band Westlife)�is bulleted at No. 35 at adult top 40. She's partnered with ION Television for its fall launch, including on-air imaging and exposure of "In This Life" and "Believe Again" (a No. 2 single in Oz). She'll appear at the American Cancer Society's fall charity Dreamball and the Jorge Posada Foundation's seventh annual Heroes of Hope Gala, hosted by Kelly Ripa, both in New York.
In addition, Goodrem recorded a duet, "Right Here With You," with fellow Aussie and cancer survivor Olivia Newton-John for the July album release "Olivia Newton-John & Friends: A Celebration in Song," with proceeds to benefit her Cancer and Wellness Centre.
"It's even more rewarding that I get to come back and start properly," Goodrem says of her U.S. relaunch. "I'm hungry for this and committed to being a new artist. I feel like I was always meant to do this, like there's a chip in my body that says, 'OK, what's next?'"
Additional reporting by Christie Eliezer in Melbourne and Andre Paine in London.
More info
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